Stem Cell Supernatant Therapy

What is Stem Cell Supernatant?

Stem cell supernatant is the nutrient-rich fluid collected from stem cell cultures. While stem cells themselves are powerful, much of their regenerative effect actually comes from the healing proteins, growth factors, cytokines, and exosomes they release into their surrounding environment.

Supernatant therapy delivers these powerful molecules without the cells themselves, making it a safe, non-cell-based option that supports tissue repair, regeneration, and rejuvenation.

Supernatant can be administered in two ways:

  • IV Infusion: Provides systemic benefits such as anti-aging, immune modulation, and overall wellness.
  • Local Injection: Targets specific areas (e.g., skin, scalp, or joints) for focused regeneration.

Why Stem Cell Supernatant Therapy?

Patients often ask why supernatant is different from stem cell therapy. Unlike stem cells that regenerate tissue directly, supernatant works by:

  • Delivering thousands of signaling molecules that trigger healing and regeneration
  • Reducing inflammation and oxidative stress throughout the body
  • Supporting cell-to-cell communication for more efficient repair
  • Offering a non-cell-based option for patients not eligible for stem cell therapy

Potential Benefits

IV Supernatant Therapy

Anti-aging and vitality enhancement

Improved immune balance and recovery from illness

Reduced systemic inflammation linked to chronic conditions

Support for fatigue, skin aging, and lifestyle-related diseases

Local Supernatant Therapy

Skin rejuvenation: Improved elasticity, hydration, and reduced wrinkles

Hair restoration: Stimulates hair follicles, improves scalp health, and reduces thinning

Joint support: Decreases inflammation and promotes repair in arthritis or injury

Enhanced results when combined with stem cell injections

Procedure

Step 1.

Consultation

Online or in-person (30–60 minutes, available in English, Japanese, or Chinese).

Step 2.

Treatment

On the same day, the supernatant is administered intravenously or injected into the target site.

  • No surgery, no downtime — most patients resume normal activities the same day

FAQs

What are exosomes (supernatant)?

Exosomes are nano-sized extracellular vesicles released by stem cells.
They act as biological messengers that support cellular communication, tissue repair, and regeneration.

Exosomes contain a rich mixture of bioactive components, including:

  • miRNA
  • mRNA
  • Cytokines
  • Growth factors
  • Lipids and structural proteins

These components help regulate gene expression, reduce oxidative stress, and promote cellular repair.

Supernatant is collected from stem cell cultures under strict sterile laboratory conditions, then carefully purified and processed for medical use to ensure safety, potency, and consistency.

Exosomes work through biochemical signaling, delivering regenerative messages to target cells.
They help:

  • Reduce inflammation
  • Enhance cellular repair
  • Improve tissue regeneration
  • Support healing without cell engraftment

Yes — supernatant contains no live cells, only naturally secreted proteins and growth factors. This reduces risks such as rejection or tumor formation, while still delivering strong regenerative effects. Treatments are performed in our GMP-compliant, ISO Class 1 cleanroom, following all Ministry of Health, Labour and Welfare (MHLW) guidelines.

Many patients notice improvements in skin quality, energy levels, or reduced inflammation within a few weeks.
Benefits may continue to develop over several months, depending on the individual and treatment goals.

Yes. Supernatant is often combined with stem cell therapy to enhance and amplify regenerative effects, as it reinforces the healing signals released by stem cells.

Supernatant therapy may be suitable for:

  • Individuals seeking anti-aging and wellness support
  • Patients looking for skin or hair rejuvenation without invasive procedures
  • Those with joint pain or inflammation
  • People who want the benefits of stem cell therapy without cell extraction
  • Patients interested in advanced regenerative treatments

Supernatant products are cryopreserved at –30°C and thawed immediately before administration to maintain potency, stability, and safety.